 World: Olympic Games - Singles - Main |
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| 1/16-finals | Basilashvili N. | Sonego L. | 2:1 (6:4, 3:6, 6:4) | details | 26.07.2021 |
| 1/32-finals | Daniel T. | Sonego L. | 1:2 (6:4, 66:7, 63:7) | details | 24.07.2021 |
 United Kingdom: Wimbledon - Singles - Main |
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| 1/8-finals | Federer R. | Sonego L. | 3:0 (7:5, 6:4, 6:2) | details | 05.07.2021 |
| 1/16-finals | Sonego L. | Duckworth J. | 3:0 (6:3, 6:4, 6:4) | details | 03.07.2021 |
| 1/32-finals | Sonego L. | Galan Riveros D. E. | 3:1 (4:6, 6:3, 7:63, 6:1) | details | 01.07.2021 |
| 1/64-finals | Sonego L. | Sousa P. | 3:0 (6:2, 7:5, 6:0) | details | 30.06.2021 |
| United Kingdom: Eastbourne - Singles - Main |
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| Final | Sonego L. | De Minaur A. | 1:2 (6:4, 4:6, 65:7) | details | 26.06.2021 |
| Semi-finals | Purcell M. | Sonego L. | 1:2 (1:6, 6:3, 1:6) | details | 25.06.2021 |
| Quarter-finals | Sonego L. | Bublik A. | 2:0 (6:1, 7:5) | details | 24.06.2021 |
| 1/8-finals | Sonego L. | Millman J. | 2:0 (6:4, 6:2) | details | 23.06.2021 |
| United Kingdom: London - Singles - Main |
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| 1/16-finals | Sonego L. | Troicki V. | 0:2 (4:6, 4:6) | details | 14.06.2021 |
 France: French Open - Singles - Main |
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| 1/64-finals | Harris L. | Sonego L. | 3:0 (7:5, 6:4, 6:4) | details | 31.05.2021 |
 Italy: Parma - Singles - Main |
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| 1/8-finals | Sonego L. | Korda S. | 0:2 (1:6, 5:7) | details | 26.05.2021 |
| France: Lyon - Singles - Main |
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| 1/16-finals | Auger-Aliassime F. | Sonego L. | CAN. | details | 17.05.2021 |
| Italy: Rome - Singles - Main |
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| Semi-finals | Djokovic N. | Sonego L. | 2:1 (6:3, 65:7, 6:2) | details | 15.05.2021 |
| Quarter-finals | Sonego L. | Rublev A. | 2:1 (3:6, 6:4, 6:3) | details | 15.05.2021 |
| 1/8-finals | Thiem D. | Sonego L. | 1:2 (4:6, 7:65, 65:7) | details | 13.05.2021 |
| 1/16-finals | Mager G. | Sonego L. | 0:2 (4:6, 4:6) | details | 12.05.2021 |
| 1/32-finals | Sonego L. | Monfils G. | 2:1 (6:4, 5:7, 6:4) | details | 11.05.2021 |
 Monaco: Monte Carlo - Singles - Main |
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| 1/16-finals | Sonego L. | Zverev A. | 0:2 (3:6, 3:6) | details | 14.04.2021 |
| 1/32-finals | Sonego L. | Fucsovics M. | 2:0 (6:3, 6:4) | details | 13.04.2021 |
| Italy: Cagliari - Singles - Main |
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| Final | Djere L. | Sonego L. | 1:2 (6:2, 65:7, 4:6) | details | 11.04.2021 |
| Semi-finals | Sonego L. | Fritz T. | 2:1 (6:4, 5:7, 6:1) | details | 10.04.2021 |
| Quarter-finals | Hanfmann Y. | Sonego L. | 1:2 (6:3, 66:7, 3:6) | details | 09.04.2021 |
| 1/8-finals | Simon G. | Sonego L. | 0:2 (4:6, 1:6) | details | 08.04.2021 |
 USA: Miami - Singles - Main |
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| 1/8-finals | Sonego L. | Tsitsipas S. | 0:2 (2:6, 62:7) | details | 31.03.2021 |
| 1/16-finals | Galan Riveros D. E. | Sonego L. | 0:2 (66:7, 3:6) | details | 29.03.2021 |
| 1/32-finals | Fratangelo B. | Sonego L. | 0:2 (4:6, 65:7) | details | 27.03.2021 |
 United Arab Emirates: Dubai - Singles - Main |
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| 1/8-finals | Sonego L. | Karatsev A. | 1:2 (6:3, 3:6, 4:6) | details | 17.03.2021 |
| 1/16-finals | Sonego L. | Zapata Miralles B. | 2:0 (6:2, 6:2) | details | 16.03.2021 |
| 1/32-finals | Davidovich Fokina A. | Sonego L. | CAN. | details | 14.03.2021 |
 Qatar: Doha - Singles - Main |
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| 1/16-finals | Sonego L. | Fritz T. | 0:2 (65:7, 4:6) | details | 08.03.2021 |
 Netherlands: Rotterdam - Singles - Main |
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| 1/16-finals | Paul T. | Sonego L. | 2:0 (6:4, 7:67) | details | 03.03.2021 |
| France: Montpellier - Singles - Main |
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| Quarter-finals | Sonego L. | Goffin D. | 0:2 (4:6, 4:6) | details | 26.02.2021 |
| 1/8-finals | Sonego L. | Korda S. | 2:0 (6:3, 6:2) | details | 24.02.2021 |
| 1/16-finals | Sonego L. | Gaston H. | 2:1 (6:3, 67:7, 6:1) | details | 22.02.2021 |
Australia: Australian Open - Doubles - Main