 United Arab Emirates: World Tennis League - Singles - Main |
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| | Seppi A. | Zverev A. | 0:2 (4:6, 2:6) | details | 23.12.2022 |
 Italy: Ortisei - Singles - Main |
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| 1/16-finals | Seppi A. | Hanfmann Y. | 1:2 (7:5, 3:6, 4:6) | details | 25.10.2022 |
| Italy: Florence - Singles - Qualification |
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| Semi-finals | Ymer M. | Seppi A. | 2:0 (7:5, 6:3) | details | 08.10.2022 |
 Bulgaria: Sofia - Singles - Qualification |
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| Final | Blancaneaux G. | Seppi A. | 2:1 (2:6, 6:3, 6:4) | details | 26.09.2022 |
| Semi-finals | Donski A. | Seppi A. | 0:2 (4:6, 2:6) | details | 25.09.2022 |
 USA: US Open - Singles - Qualification |
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| Final | Bagnis F. | Seppi A. | 2:0 (7:5, 6:2) | details | 27.08.2022 |
| Semi-finals | Seppi A. | Pospisil V. | 2:1 (3:6, 6:2, 7:5) | details | 26.08.2022 |
| Quarter-finals | Seppi A. | Horansky F. | 2:1 (6:4, 5:7, 6:2) | details | 25.08.2022 |
 Croatia: Umag - Singles - Qualification |
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| Final | Seppi A. | Cecchinato M. | WO. | details | 24.07.2022 |
| Semi-finals | Cobolli F. | Seppi A. | 1:2 (1:6, 7:63, 4:6) | details | 23.07.2022 |
| Italy: Trieste - Singles - Main |
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| 1/16-finals | Seppi A. | Bellucci M. | 0:2 (2:6, 0:6) | details | 19.07.2022 |
 United Kingdom: Wimbledon - Singles - Qualification |
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| Final | Klein L. | Seppi A. | 3:1 (6:1, 63:7, 7:65, 7:64) | details | 23.06.2022 |
| Semi-finals | McHugh A. | Seppi A. | 0:2 (4:6, 2:6) | details | 22.06.2022 |
| Quarter-finals | Basic M. | Seppi A. | 1:2 (2:6, 6:4, 0:6) | details | 20.06.2022 |
| United Kingdom: Ilkley - Singles - Main |
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| Quarter-finals | Seppi A. | Bergs Z. | 1:2 (2:6, 7:5, 3:6) | details | 17.06.2022 |
| 1/8-finals | Borges N. | Seppi A. | 0:2 (4:6, 5:7) | details | 16.06.2022 |
| 1/16-finals | Seppi A. | Hijikata R. | 2:0 (6:4, 6:1) | details | 14.06.2022 |
 Netherlands: Hertogenbosch - Singles - Main |
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| 1/16-finals | Mannarino A. | Seppi A. | 2:0 (7:64, 7:69) | details | 07.06.2022 |
| Netherlands: Hertogenbosch - Singles - Qualification |
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| Final | Seppi A. | Brouwer G. | 2:1 (7:5, 65:7, 6:3) | details | 06.06.2022 |
| Semi-finals | Seppi A. | Klahn B. | 2:0 (7:64, 6:1) | details | 04.06.2022 |
| Italy: Vicenza - Singles - Main |
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| 1/16-finals | Seppi A. | Arnaboldi A. | 0:2 (1:6, 65:7) | details | 24.05.2022 |
 France: French Open - Singles - Qualification |
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| Quarter-finals | Zeppieri G. | Seppi A. | 2:0 (6:3, 6:4) | details | 16.05.2022 |
| USA: Miami - Singles - Qualification |
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| Final | Kokkinakis T. | Seppi A. | 2:0 (6:3, 6:4) | details | 22.03.2022 |
| Semi-finals | Machac T. | Seppi A. | 1:2 (6:2, 3:6, 2:6) | details | 21.03.2022 |
| USA: Indian Wells - Singles - Qualification |
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| Semi-finals | Kukushkin M. | Seppi A. | 2:0 (6:2, 6:4) | details | 08.03.2022 |
 Mexico: Acapulco - Singles - Qualification |
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| Semi-finals | Wolf J.J. | Seppi A. | 2:0 (6:4, 6:2) | details | 20.02.2022 |
| USA: Delray Beach - Singles - Main |
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| 1/8-finals | Seppi A. | Korda S. | 0:2 (5:7, 3:6) | details | 17.02.2022 |
| 1/16-finals | Gojowczyk P. | Seppi A. | 0:2 (5:7, 4:6) | details | 14.02.2022 |
| USA: Dallas - Singles - Main |
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| 1/8-finals | Brooksby J. | Seppi A. | 2:1 (6:3, 3:6, 6:3) | details | 10.02.2022 |
| 1/16-finals | Altmaier D. | Seppi A. | 1:2 (6:4, 3:6, 4:6) | details | 09.02.2022 |
| USA: Cleveland - Singles - Main |
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| 1/16-finals | Stricker D. | Seppi A. | 2:0 (6:4, 6:4) | details | 01.02.2022 |
 Australia: Australian Open - Singles - Main |
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| 1/64-finals | Seppi A. | Majchrzak K. | 0:3 (1:6, 1:6, 5:7) | details | 18.01.2022 |
| Australia: Sydney - Singles - Qualification |
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| Semi-finals | O'Connell C. | Seppi A. | 2:0 (6:4, 6:3) | details | 09.01.2022 |
| Australia: Melbourne (Summer Set) - Singles - Main |
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| 1/16-finals | Molcan A. | Seppi A. | 2:1 (6:4, 66:7, 6:3) | details | 05.01.2022 |
| Australia: Melbourne (Summer Set) - Singles - Qualification |
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| Final | Baez S. | Seppi A. | 0:2 (5:7, 61:7) | details | 04.01.2022 |
| Semi-finals | Zapata Miralles B. | Seppi A. | 0:2 (4:6, 63:7) | details | 03.01.2022 |
| France: Paris - Singles - Qualification |
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| Final | Seppi A. | Ymer M. | 0:2 (2:6, 1:6) | details | 31.10.2021 |
| Semi-finals | Martinez P. | Seppi A. | 0:2 (5:7, 3:6) | details | 30.10.2021 |
 Germany: Ismaning - Singles - Main |
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| 1/8-finals | Zuk K. | Seppi A. | 2:1 (4:6, 6:4, 7:64) | details | 27.10.2021 |
| 1/16-finals | Kamke T. | Seppi A. | 0:2 (5:7, 3:6) | details | 25.10.2021 |
 Belgium: Antwerp - Singles - Qualification |
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| Final | Seppi A. | Novak D. | 1:2 (69:7, 6:3, 66:7) | details | 18.10.2021 |
| Semi-finals | Seppi A. | Onclin G. | 2:0 (6:4, 7:5) | details | 17.10.2021 |
| France: Mouilleron-Le-Captif - Singles - Main |
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| Semi-finals | Seppi A. | Vesely J. | 0:2 (4:6, 61:7) | details | 09.10.2021 |
| Quarter-finals | Halys Q. | Seppi A. | 1:2 (6:2, 66:7, 3:6) | details | 08.10.2021 |
| 1/8-finals | Machac T. | Seppi A. | 1:2 (63:7, 6:4, 4:6) | details | 06.10.2021 |