 USA: Miami - Singles - Main |
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| 1/64-finals | Ofner S. | Nishikori K. | 2:0 (6:3, 6:4) | details | 21.03.2024 |
| USA: US Open - Singles - Main |
|---|
| 1/64-finals | Nishikori K. | Meligeni Alves F. | CAN. | details | 29.08.2023 |
| USA: Washington - Singles - Main |
|---|
| 1/32-finals | Harris L. | Nishikori K. | CAN. | details | 01.08.2023 |
| USA: Atlanta - Singles - Main |
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| Quarter-finals | Fritz T. | Nishikori K. | 2:0 (6:4, 6:2) | details | 28.07.2023 |
| 1/8-finals | Nishikori K. | Shang J. | 2:0 (6:4, 7:63) | details | 28.07.2023 |
| 1/16-finals | Thompson J. | Nishikori K. | 0:2 (65:7, 65:7) | details | 25.07.2023 |
| USA: Chicago - Singles - Main |
|---|
| Quarter-finals | Nishikori K. | Michelsen A. | 1:2 (613:7, 6:3, 1:6) | details | 14.07.2023 |
| 1/8-finals | Nishikori K. | Mansouri S. | 2:0 (7:61, 6:4) | details | 14.07.2023 |
| 1/16-finals | Galarneau A. | Nishikori K. | 0:2 (63:7, 1:6) | details | 12.07.2023 |
| USA: Bloomfield Hills - Singles - Main |
|---|
| 1/8-finals | Kudla D. | Nishikori K. | 2:1 (6:4, 3:6, 6:3) | details | 06.07.2023 |
| 1/16-finals | Nishikori K. | Walton A. | 2:0 (6:1, 6:2) | details | 04.07.2023 |
 Puerto Rico: Palmas Del Mar - Singles - Main |
|---|
| Final | Zheng M. | Nishikori K. | 0:2 (2:6, 5:7) | details | 18.06.2023 |
| Semi-finals | Nishikori K. | Heide G. | 2:0 (6:4, 6:2) | details | 18.06.2023 |
| Quarter-finals | Nishikori K. | Walton A. | 2:0 (6:4, 6:2) | details | 17.06.2023 |
| 1/8-finals | Krueger M. | Nishikori K. | 1:2 (6:4, 3:6, 2:6) | details | 16.06.2023 |
| 1/16-finals | Langmo C. | Nishikori K. | 0:2 (2:6, 4:6) | details | 14.06.2023 |
| USA: Indian Wells - Singles - Main |
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| 1/32-finals | Nishikori K. | Evans D. | 1:2 (6:4, 3:6, 4:6) | details | 09.10.2021 |
| 1/64-finals | Nishikori K. | Sousa J. | 2:1 (65:7, 6:3, 6:2) | details | 08.10.2021 |
| USA: San Diego - Singles - Main |
|---|
| 1/16-finals | Nishikori K. | Murray A. | CAN. | details | 29.09.2021 |
| USA: US Open - Singles - Main |
|---|
| 1/16-finals | Djokovic N. | Nishikori K. | 3:1 (64:7, 6:3, 6:3, 6:2) | details | 04.09.2021 |
| 1/32-finals | Nishikori K. | McDonald M. | 3:2 (7:63, 6:3, 65:7, 2:6, 6:3) | details | 02.09.2021 |
| 1/64-finals | Caruso S. | Nishikori K. | 1:3 (1:6, 1:6, 7:5, 3:6) | details | 31.08.2021 |
 Canada: Toronto - Singles - Main |
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| 1/16-finals | Nishikori K. | Hurkacz H. | WO. | details | 11.08.2021 |
| 1/32-finals | Kecmanovic M. | Nishikori K. | 1:2 (4:6, 7:65, 2:6) | details | 10.08.2021 |
| USA: Washington - Singles - Main |
|---|
| Semi-finals | Nishikori K. | McDonald M. | 1:2 (4:6, 6:3, 5:7) | details | 08.08.2021 |
| Quarter-finals | Harris L. | Nishikori K. | 0:2 (3:6, 5:7) | details | 07.08.2021 |
| 1/8-finals | Nishikori K. | Norrie C. | 2:1 (3:6, 6:3, 6:3) | details | 05.08.2021 |
| 1/16-finals | Bublik A. | Nishikori K. | 0:2 (2:6, 5:7) | details | 04.08.2021 |
 World: Olympic Games - Singles - Main |
|---|
| Quarter-finals | Djokovic N. | Nishikori K. | 2:0 (6:2, 6:0) | details | 29.07.2021 |
| 1/8-finals | Ivashka I. | Nishikori K. | 0:2 (67:7, 0:6) | details | 28.07.2021 |
| 1/16-finals | Giron M. | Nishikori K. | 1:2 (65:7, 6:3, 1:6) | details | 27.07.2021 |
| 1/32-finals | Nishikori K. | Rublev A. | 2:0 (6:3, 6:4) | details | 25.07.2021 |
 United Kingdom: Wimbledon - Singles - Main |
|---|
| 1/32-finals | Nishikori K. | Thompson J. | 1:3 (5:7, 4:6, 7:5, 3:6) | details | 01.07.2021 |
| 1/64-finals | Nishikori K. | Popyrin A. | 3:0 (6:4, 6:4, 6:4) | details | 30.06.2021 |
 Germany: Halle - Singles - Main |
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| 1/8-finals | Nishikori K. | Korda S. | 1:2 (6:2, 3:6, 5:7) | details | 17.06.2021 |
| 1/16-finals | Berankis R. | Nishikori K. | 1:2 (3:6, 6:2, 2:6) | details | 15.06.2021 |
 France: French Open - Singles - Main |
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| 1/8-finals | Zverev A. | Nishikori K. | 3:0 (6:4, 6:1, 6:1) | details | 06.06.2021 |
| 1/16-finals | Nishikori K. | Laaksonen H. | 1:0 RET. (7:5, 0:0) | details | 04.06.2021 |
| 1/32-finals | Khachanov K. | Nishikori K. | 2:3 (6:4, 2:6, 6:2, 4:6, 4:6) | details | 02.06.2021 |
| 1/64-finals | Nishikori K. | Giannessi A. | 3:2 (6:4, 64:7, 6:3, 4:6, 6:4) | details | 30.05.2021 |
 Italy: Rome - Singles - Main |
|---|
| 1/8-finals | Zverev A. | Nishikori K. | 2:1 (4:6, 6:3, 6:4) | details | 13.05.2021 |
| 1/16-finals | Nishikori K. | Carreno-Busta P. | WO. | details | 11.05.2021 |
| 1/32-finals | Nishikori K. | Fognini F. | 2:0 (6:3, 6:4) | details | 10.05.2021 |
 Spain: Madrid - Singles - Main |
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| 1/16-finals | Nishikori K. | Zverev A. | 0:2 (3:6, 2:6) | details | 05.05.2021 |
| 1/32-finals | Khachanov K. | Nishikori K. | 1:2 (7:66, 2:6, 2:6) | details | 04.05.2021 |
 Portugal: Estoril - Singles - Main |
|---|
| 1/8-finals | Anderson K. | Nishikori K. | CAN. | details | 28.04.2021 |
