 World: Finals - Guadalajara - Doubles - Play Offs |
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| Semi-finals | Krejcikova B./Siniakova K. | Melichar-Martinez N./Schuurs D. | 2:1 (3:6, 6:3, 10:6) | details | 16.11.2021 |
| World: Finals - Guadalajara - Doubles - Main |
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| Group B | Melichar-Martinez N./Schuurs D. | Jurak Schreiber D./Klepac A. | 2:1 (6:4, 3:6, 10:2) | details | 15.11.2021 |
| Group B | Aoyama S./Shibahara E. | Melichar-Martinez N./Schuurs D. | 2:0 (6:4, 7:65) | details | 12.11.2021 |
| Group B | Melichar-Martinez N./Schuurs D. | Stosur S./Zhang S. | 2:0 (6:2, 6:2) | details | 11.11.2021 |
 USA: Indian Wells - Doubles - Main |
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| 1/8-finals | Melichar-Martinez N./Schuurs D. | Fernandez L./Gauff C. | 0:2 (3:6, 2:6) | details | 10.10.2021 |
| 1/16-finals | Melichar-Martinez N./Schuurs D. | Peschke K./Rus A. | 2:0 (6:4, 6:3) | details | 08.10.2021 |
| USA: Chicago 2 - Doubles - Main |
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| Semi-finals | Melichar-Martinez N./Schuurs D. | Peschke K./Petkovic A. | 0:2 (64:7, 4:6) | details | 02.10.2021 |
| Quarter-finals | Hsieh S-W./Mertens E. | Melichar-Martinez N./Schuurs D. | WO. | details | 02.10.2021 |
| 1/8-finals | Kichenok N./Olaru R. | Melichar-Martinez N./Schuurs D. | 1:2 (6:4, 5:7, 3:10) | details | 30.09.2021 |
| 1/16-finals | Bektas E./Moore T. | Melichar-Martinez N./Schuurs D. | 0:2 (67:7, 3:6) | details | 27.09.2021 |
| USA: US Open - Doubles - Main |
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| 1/32-finals | Melichar-Martinez N./Schuurs D. | Rodionova An./Rodionova Ar. | 0:2 (2:6, 4:6) | details | 02.09.2021 |
| USA: Chicago - Doubles - Main |
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| Quarter-finals | Melichar-Martinez N./Schuurs D. | Martincova T./Vondrousova M. | 1:2 (6:1, 4:6, 9:11) | details | 25.08.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Christian K./Hibino N. | 2:0 (6:2, 7:65) | details | 24.08.2021 |
| USA: Cincinnati - Doubles - Main |
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| Quarter-finals | Melichar-Martinez N./Schuurs D. | Stosur S./Zhang S. | 1:2 (3:6, 7:65, 4:10) | details | 20.08.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Kudermetova V./Rybakina E. | 2:0 (6:4, 6:4) | details | 20.08.2021 |
 Canada: Montreal - Doubles - Main |
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| 1/8-finals | Melichar-Martinez N./Schuurs D. | Eikeri U./Harrison C. | 1:2 (3:6, 6:2, 4:10) | details | 11.08.2021 |
 United Kingdom: Wimbledon - Doubles - Main |
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| 1/32-finals | Melichar-Martinez N./Schuurs D. | Mitu A./Niculescu M. | 0:2 (2:6, 3:6) | details | 02.07.2021 |
| United Kingdom: Eastbourne - Doubles - Main |
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| Final | Melichar-Martinez N./Schuurs D. | Aoyama S./Shibahara E. | 0:2 (1:6, 4:6) | details | 26.06.2021 |
| Semi-finals | Melichar-Martinez N./Schuurs D. | Chan H-C./Chan L. | 2:1 (7:61, 4:6, 10:5) | details | 25.06.2021 |
| Quarter-finals | Melichar-Martinez N./Schuurs D. | McHale C./Santamaria S. | 2:0 (6:4, 7:5) | details | 24.06.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Andreescu B./Putintseva Y. | 2:1 (4:6, 7:5, 10:5) | details | 23.06.2021 |
 Germany: Berlin - Doubles - Main |
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| Final | Melichar-Martinez N./Schuurs D. | Azarenka V./Sabalenka A. | 1:2 (6:4, 5:7, 4:10) | details | 20.06.2021 |
| Semi-finals | Melichar-Martinez N./Schuurs D. | Kudermetova V./Vondrousova M. | 2:0 (7:5, 6:3) | details | 18.06.2021 |
| Quarter-finals | Melichar-Martinez N./Schuurs D. | Kato M./Voracova R. | 2:0 (6:1, 6:3) | details | 16.06.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Heisen V./Peschke K. | 2:0 (6:4, 6:2) | details | 15.06.2021 |
 France: French Open - Doubles - Main |
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| 1/8-finals | Pavlyuchenkova A./Rybakina E. | Melichar-Martinez N./Schuurs D. | 2:0 (6:4, 6:3) | details | 07.06.2021 |
| 1/16-finals | Mitu A./Putintseva Y. | Melichar-Martinez N./Schuurs D. | 0:2 (2:6, 0:6) | details | 04.06.2021 |
| 1/32-finals | Parry D./Yerolymos M. | Melichar-Martinez N./Schuurs D. | 0:2 (5:7, 4:6) | details | 02.06.2021 |
 Italy: Rome - Doubles - Main |
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| 1/8-finals | Vesnina E./Zvonareva V. | Melichar-Martinez N./Schuurs D. | 2:1 (7:5, 1:6, 11:9) | details | 13.05.2021 |
| USA: Charleston - Doubles - Main |
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| Final | Melichar-Martinez N./Schuurs D. | Bouzkova M./Hradecka L. | 2:0 (6:2, 6:4) | details | 11.04.2021 |
| Semi-finals | Melichar-Martinez N./Schuurs D. | Dabrowski G./Muhammad A. | 2:0 (7:5, 6:1) | details | 10.04.2021 |
| Quarter-finals | Melichar-Martinez N./Schuurs D. | Jabeur O./Potapova A. | 2:0 (6:3, 6:2) | details | 08.04.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Perez E./Vandeweghe C. | 2:1 (3:6, 6:1, 10:4) | details | 05.04.2021 |
| USA: Miami - Doubles - Main |
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| 1/16-finals | Muhammad A./Pegula J. | Melichar-Martinez N./Schuurs D. | 2:0 (6:2, 6:2) | details | 27.03.2021 |
| 1/16-finals | Siegemund L./Vondrousova M. | Melichar-Martinez N./Schuurs D. | CAN. | details | 26.03.2021 |
 United Arab Emirates: Dubai - Doubles - Main |
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| Quarter-finals | Melichar-Martinez N./Schuurs D. | Guarachi A./Jurak Schreiber D. | 1:2 (3:6, 6:4, 3:10) | details | 11.03.2021 |
| 1/8-finals | Melichar-Martinez N./Schuurs D. | Bertens K./Pattinama Kerkhove L. | 2:0 (6:3, 6:2) | details | 10.03.2021 |
 Qatar: Doha - Doubles - Main |
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| Final | Niculescu M./Ostapenko J. | Melichar-Martinez N./Schuurs D. | 1:2 (2:6, 6:2, 8:10) | details | 05.03.2021 |
| Semi-finals | Klepac A./Mirza S. | Melichar-Martinez N./Schuurs D. | 1:2 (5:7, 6:2, 5:10) | details | 04.03.2021 |
| Quarter-finals | Mattek-Sands B./Pegula J. | Melichar-Martinez N./Schuurs D. | 0:2 (1:6, 1:6) | details | 03.03.2021 |
| 1/8-finals | Guarachi A./Jurak Schreiber D. | Melichar-Martinez N./Schuurs D. | 0:2 (2:6, 3:6) | details | 02.03.2021 |
 Australia: Australian Open - Doubles - Main |
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| Semi-finals | Melichar-Martinez N./Schuurs D. | Mertens E./Sabalenka A. | 0:2 (5:7, 4:6) | details | 17.02.2021 |
| Quarter-finals | Gauff C./McNally C. | Melichar-Martinez N./Schuurs D. | 0:2 (64:7, 1:6) | details | 16.02.2021 |
| 1/8-finals | Kichenok L./Ostapenko J. | Melichar-Martinez N./Schuurs D. | 0:2 (2:6, 4:6) | details | 15.02.2021 |
| 1/16-finals | Lapko V./Vondrousova M. | Melichar-Martinez N./Schuurs D. | 0:2 (2:6, 4:6) | details | 13.02.2021 |
| 1/32-finals | Ferro F./Teichmann J. | Melichar-Martinez N./Schuurs D. | 0:0 RET. (2:3) | details | 11.02.2021 |
| Australia: Melbourne (Yarra Valley Classic) - Doubles - Main |
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| Semi-finals | Aoyama S./Shibahara E. | Melichar-Martinez N./Schuurs D. | 2:1 (65:7, 7:5, 13:11) | details | 06.02.2021 |
| Quarter-finals | Barty A./Brady J. | Melichar-Martinez N./Schuurs D. | 0:2 (5:7, 4:6) | details | 05.02.2021 |
| 1/8-finals | Ferro F./Teichmann J. | Melichar-Martinez N./Schuurs D. | 0:2 (61:7, 2:6) | details | 02.02.2021 |
| United Arab Emirates: Abu Dhabi - Doubles - Main |
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| 1/8-finals | Kudermetova V./Potapova A. | Melichar-Martinez N./Schuurs D. | 2:0 (6:2, 6:2) | details | 09.01.2021 |
