 USA: Las Vegas - Singles - Main |
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| 1/16-finals | Johnson S. | Karlovic I. | CAN. | details | 26.10.2021 |
| USA: Indian Wells - Singles - Qualification |
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| Semi-finals | Gomez E. | Karlovic I. | 2:0 (6:3, 7:67) | details | 06.10.2021 |
| Quarter-finals | Schnur B. | Karlovic I. | 1:2 (6:4, 65:7, 67:7) | details | 05.10.2021 |
| USA: US Open - Singles - Main |
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| 1/64-finals | Rublev A. | Karlovic I. | 3:0 (6:3, 7:63, 6:3) | details | 30.08.2021 |
| USA: US Open - Singles - Qualification |
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| Final | Sugita Y. | Karlovic I. | 0:2 (3:6, 65:7) | details | 27.08.2021 |
| Semi-finals | Karlovic I. | Dellien H. | 2:1 (7:5, 61:7, 6:2) | details | 27.08.2021 |
| Quarter-finals | Karlovic I. | Milojevic N. | 2:0 (6:4, 7:61) | details | 25.08.2021 |
| USA: Washington - Singles - Qualification |
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| Semi-finals | Karlovic I. | Marchenko I. | 1:2 (3:6, 7:610, 3:6) | details | 31.07.2021 |
 Mexico: Los Cabos - Singles - Main |
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| 1/16-finals | Thompson J. | Karlovic I. | 2:0 (6:4, 7:5) | details | 21.07.2021 |
| USA: Newport - Singles - Main |
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| 1/8-finals | Bublik A. | Karlovic I. | 2:1 (7:65, 4:6, 6:1) | details | 14.07.2021 |
| 1/16-finals | Karlovic I. | Zapata Miralles B. | 2:1 (65:7, 6:1, 6:4) | details | 13.07.2021 |
 United Kingdom: Wimbledon - Singles - Qualification |
|---|
| Quarter-finals | Safiullin R. | Karlovic I. | 2:0 (6:3, 6:4) | details | 22.06.2021 |
| USA: Tallahassee - Singles - Main |
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| 1/16-finals | Karlovic I. | Fratangelo B. | 1:2 (65:7, 7:63, 64:7) | details | 20.04.2021 |
| USA: Miami - Singles - Qualification |
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| Final | McDonald M. | Karlovic I. | 2:0 (7:63, 6:4) | details | 23.03.2021 |
| Semi-finals | Ito T. | Karlovic I. | 0:2 (3:6, 63:7) | details | 22.03.2021 |
| USA: Delray Beach - Singles - Main |
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| 1/8-finals | Quiroz R. | Karlovic I. | 2:0 (6:2, 6:4) | details | 11.01.2021 |
| 1/16-finals | Karlovic I. | Andujar P. | 2:1 (6:3, 5:7, 6:4) | details | 09.01.2021 |
 Germany: Cologne - Singles - Qualification |
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| Semi-finals | Karlovic I. | Polmans M. | 0:2 (1:6, 4:6) | details | 10.10.2020 |
 France: French Open - Singles - Qualification |
|---|
| Semi-finals | Bonzi B. | Karlovic I. | 2:0 (6:3, 7:63) | details | 23.09.2020 |
| Quarter-finals | Rubin N. | Karlovic I. | 0:2 (61:7, 4:6) | details | 21.09.2020 |
| USA: US Open - Singles - Main |
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| 1/64-finals | Karlovic I. | Gasquet R. | 0:3 (60:7, 64:7, 1:6) | details | 02.09.2020 |
| USA: MatchPlay 120 - Singles - Main |
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| | Aragone J. | Karlovic I. | 2:0 (7:65, 7:5) | details | 12.06.2020 |
 Canada: Calgary - Singles - Main |
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| 1/8-finals | Karlovic I. | Blancaneaux G. | 0:2 (67:7, 4:6) | details | 27.02.2020 |
| 1/16-finals | Karlovic I. | King E. | 2:0 (7:62, 6:4) | details | 26.02.2020 |
| USA: New York - Singles - Main |
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| 1/16-finals | Karlovic I. | Thompson J. | 0:2 (3:6, 62:7) | details | 11.02.2020 |
 India: Pune - Singles - Main |
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| 1/16-finals | Stebe C. | Karlovic I. | 2:0 (6:3, 6:4) | details | 03.02.2020 |
 Australia: Australian Open - Singles - Main |
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| 1/32-finals | Monfils G. | Karlovic I. | 3:1 (4:6, 7:68, 6:4, 7:5) | details | 23.01.2020 |
| 1/64-finals | Karlovic I. | Pospisil V. | 3:0 (7:64, 6:4, 7:5) | details | 21.01.2020 |
 Qatar: Doha - Singles - Qualification |
|---|
| Semi-finals | Vesely J. | Karlovic I. | 2:1 (610:7, 6:3, 6:2) | details | 04.01.2020 |
| USA: Houston - Singles - Main |
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| Final | Giron M. | Karlovic I. | 2:1 (7:5, 65:7, 7:69) | details | 17.11.2019 |
| Semi-finals | Karlovic I. | O'Connell C. | 2:1 (65:7, 6:3, 6:4) | details | 16.11.2019 |
| Quarter-finals | Galarneau A. | Karlovic I. | 0:2 (63:7, 67:7) | details | 15.11.2019 |
| 1/8-finals | Bangoura S. | Karlovic I. | 1:2 (65:7, 6:2, 4:6) | details | 15.11.2019 |
| 1/16-finals | Caruana L. | Karlovic I. | 0:2 (5:7, 4:6) | details | 12.11.2019 |
| USA: Charlottesville - Singles - Main |
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| 1/16-finals | Peliwo F. | Karlovic I. | 2:0 (6:1, 7:5) | details | 29.10.2019 |
 Switzerland: Basel - Singles - Qualification |
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| Semi-finals | Gojowczyk P. | Karlovic I. | 2:0 (6:2, 6:4) | details | 19.10.2019 |
 Russia: Moscow - Singles - Main |
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| 1/8-finals | Cilic M. | Karlovic I. | 2:0 (6:1, 7:65) | details | 17.10.2019 |
| 1/16-finals | Karlovic I. | Bedene A. | 2:1 (6:4, 65:7, 7:66) | details | 15.10.2019 |
| USA: Cincinnati - Singles - Main |
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| 1/32-finals | Karlovic I. | Struff J-L. | 0:2 (5:7, 64:7) | details | 12.08.2019 |
| USA: Cincinnati - Singles - Qualification |
|---|
| Final | Kohlschreiber P. | Karlovic I. | 1:2 (64:7, 7:61, 4:6) | details | 11.08.2019 |
| Semi-finals | Karlovic I. | Sandgren T. | 2:1 (4:6, 6:4, 7:66) | details | 10.08.2019 |
| Canada: Montreal - Singles - Qualification |
|---|
| Final | Lopez F. | Karlovic I. | WO. | details | 04.08.2019 |
| Semi-finals | Donskoy E. | Karlovic I. | 1:2 (4:6, 6:4, 63:7) | details | 03.08.2019 |
| USA: Washington - Singles - Main |
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| 1/32-finals | Fratangelo B. | Karlovic I. | 2:1 (6:4, 614:7, 7:65) | details | 29.07.2019 |
| USA: Newport - Singles - Main |
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| 1/16-finals | Karlovic I. | Andreozzi G. | 0:2 (66:7, 67:7) | details | 15.07.2019 |
| United Kingdom: Wimbledon - Singles - Main |
|---|
| 1/32-finals | Karlovic I. | Fabbiano T. | 2:3 (3:6, 7:66, 3:6, 7:64, 4:6) | details | 03.07.2019 |
| 1/64-finals | Arnaboldi A. | Karlovic I. | 0:3 (4:6, 4:6, 64:7) | details | 01.07.2019 |
| United Kingdom: London - Singles - Qualification |
|---|
| Final | Karlovic I. | Ward J. | 0:2 (64:7, 4:6) | details | 16.06.2019 |
| Semi-finals | Karlovic I. | Polansky P. | 2:0 (6:3, 7:5) | details | 15.06.2019 |
