| Conference | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 16 | 13 | 3 | 0 | 36:10 | 26 | 42 | |
| 2. | Phoenix Rising | 16 | 11 | 5 | 0 | 41:12 | 29 | 38 | |
| 3. | New Mexico | 16 | 9 | 6 | 1 | 29:15 | 14 | 33 | |
| 4. | San Diego Loyal | 16 | 9 | 2 | 5 | 28:20 | 8 | 29 | |
| 5. | Rio Grande | 16 | 9 | 2 | 5 | 28:21 | 7 | 29 | |
| 6. | Colorado Springs | 16 | 8 | 5 | 3 | 31:20 | 11 | 29 | |
| 7. | Tacoma Defiance | 16 | 8 | 4 | 4 | 24:16 | 8 | 28 | |
| 8. | San Antonio | 16 | 7 | 6 | 3 | 27:16 | 11 | 27 | |
| 9. | Oakland Roots | 16 | 7 | 4 | 5 | 19:16 | 3 | 25 | |
| 10. | Orange County SC | 16 | 7 | 4 | 5 | 21:20 | 1 | 25 | |
| 11. | Austin Bold | 16 | 6 | 7 | 3 | 18:16 | 2 | 25 | |
| 12. | Ventura County | 16 | 4 | 5 | 7 | 31:25 | 6 | 17 | |
| 13. | Sacramento Republic | 16 | 4 | 5 | 7 | 19:23 | -4 | 17 | |
| 14. | Real Monarchs | 16 | 4 | 5 | 7 | 18:25 | -7 | 17 | |
| 15. | Las Vegas Lights | 16 | 3 | 2 | 11 | 22:34 | -12 | 11 | |
| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | Tampa Bay | 16 | 13 | 1 | 2 | 37:10 | 27 | 40 | |
| 2. | Charlotte Independ. | 16 | 12 | 3 | 1 | 36:14 | 22 | 39 | |
| 3. | Louisville City | 16 | 12 | 2 | 2 | 37:17 | 20 | 38 | |
| 4. | Miami FC | 16 | 11 | 1 | 4 | 32:18 | 14 | 34 | |
| 5. | Birmingham | 16 | 10 | 2 | 4 | 31:16 | 15 | 32 | |
| 6. | Pittsburgh | 16 | 9 | 4 | 3 | 27:13 | 14 | 31 | |
| 7. | Memphis | 16 | 9 | 3 | 4 | 26:18 | 8 | 30 | |
| 8. | FC Tulsa | 16 | 9 | 1 | 6 | 30:23 | 7 | 28 | |
| 9. | Hartford Athletic | 16 | 7 | 3 | 6 | 29:20 | 9 | 24 | |
| 10. | Charleston | 16 | 7 | 3 | 6 | 26:25 | 1 | 24 | |
| 11. | Oklahoma City Energy | 16 | 4 | 8 | 4 | 15:13 | 2 | 20 | |
| 12. | Indy Eleven | 16 | 5 | 4 | 7 | 14:16 | -2 | 19 | |
| 13. | Atlanta United 2 | 16 | 4 | 7 | 5 | 26:24 | 2 | 19 | |
| 14. | New York Red Bulls 2 | 16 | 3 | 3 | 10 | 22:30 | -8 | 12 | |
| 15. | Sporting Kansas City II | 16 | 2 | 5 | 9 | 16:27 | -11 | 11 | |
| 16. | Loudoun | 16 | 3 | 1 | 12 | 20:39 | -19 | 10 | |
| Division | |||||||||
| # | Atlantic Division | MP | W | D | L | G | GD | Pts | Form |
| 1. | Tampa Bay | 16 | 13 | 1 | 2 | 37:10 | 27 | 40 | |
| 2. | Charlotte Independ. | 16 | 12 | 3 | 1 | 36:14 | 22 | 39 | |
| 3. | Miami FC | 16 | 11 | 1 | 4 | 32:18 | 14 | 34 | |
| 4. | Pittsburgh | 16 | 9 | 4 | 3 | 27:13 | 14 | 31 | |
| 5. | Hartford Athletic | 16 | 7 | 3 | 6 | 29:20 | 9 | 24 | |
| 6. | Charleston | 16 | 7 | 3 | 6 | 26:25 | 1 | 24 | |
| 7. | New York Red Bulls 2 | 16 | 3 | 3 | 10 | 22:30 | -8 | 12 | |
| 8. | Loudoun | 16 | 3 | 1 | 12 | 20:39 | -19 | 10 | |
| # | Central Division | MP | W | D | L | G | GD | Pts | Form |
| 1. | Louisville City | 16 | 12 | 2 | 2 | 37:17 | 20 | 38 | |
| 2. | Birmingham | 16 | 10 | 2 | 4 | 31:16 | 15 | 32 | |
| 3. | Memphis | 16 | 9 | 3 | 4 | 26:18 | 8 | 30 | |
| 4. | FC Tulsa | 16 | 9 | 1 | 6 | 30:23 | 7 | 28 | |
| 5. | Oklahoma City Energy | 16 | 4 | 8 | 4 | 15:13 | 2 | 20 | |
| 6. | Indy Eleven | 16 | 5 | 4 | 7 | 14:16 | -2 | 19 | |
| 7. | Atlanta United 2 | 16 | 4 | 7 | 5 | 26:24 | 2 | 19 | |
| 8. | Sporting Kansas City II | 16 | 2 | 5 | 9 | 16:27 | -11 | 11 | |
| # | Pacific Division | MP | W | D | L | G | GD | Pts | Form |
| 1. | Phoenix Rising | 16 | 11 | 5 | 0 | 41:12 | 29 | 38 | |
| 2. | San Diego Loyal | 16 | 9 | 2 | 5 | 28:20 | 8 | 29 | |
| 3. | Tacoma Defiance | 16 | 8 | 4 | 4 | 24:16 | 8 | 28 | |
| 4. | Oakland Roots | 16 | 7 | 4 | 5 | 19:16 | 3 | 25 | |
| 5. | Orange County SC | 16 | 7 | 4 | 5 | 21:20 | 1 | 25 | |
| 6. | Ventura County | 16 | 4 | 5 | 7 | 31:25 | 6 | 17 | |
| 7. | Sacramento Republic | 16 | 4 | 5 | 7 | 19:23 | -4 | 17 | |
| 8. | Las Vegas Lights | 16 | 3 | 2 | 11 | 22:34 | -12 | 11 | |
| # | Mountain Division | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 16 | 13 | 3 | 0 | 36:10 | 26 | 42 | |
| 2. | New Mexico | 16 | 9 | 6 | 1 | 29:15 | 14 | 33 | |
| 3. | Rio Grande | 16 | 9 | 2 | 5 | 28:21 | 7 | 29 | |
| 4. | Colorado Springs | 16 | 8 | 5 | 3 | 31:20 | 11 | 29 | |
| 5. | San Antonio | 16 | 7 | 6 | 3 | 27:16 | 11 | 27 | |
| 6. | Austin Bold | 16 | 6 | 7 | 3 | 18:16 | 2 | 25 | |
| 7. | Real Monarchs | 16 | 4 | 5 | 7 | 18:25 | -7 | 17 | |