| # | Group A | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Reno | 5 | 3 | 2 | 0 | 13:8 | 5 | 11 | |
| 2. | Tacoma Defiance | 5 | 2 | 1 | 2 | 8:9 | -1 | 7 | |
| 3. | Portland Timbers 2 | 5 | 2 | 0 | 3 | 8:13 | -5 | 6 | |
| 4. | Sacramento Republic | 5 | 1 | 3 | 1 | 11:8 | 3 | 6 | |
| # | Group B | MP | W | D | L | G | GD | Pts | Form |
| 1. | Phoenix Rising | 5 | 4 | 0 | 1 | 15:5 | 10 | 12 | |
| 2. | San Diego Loyal | 5 | 3 | 1 | 1 | 9:6 | 3 | 10 | |
| 3. | Ventura County | 5 | 2 | 2 | 1 | 10:10 | 0 | 8 | |
| 4. | Orange County SC | 5 | 2 | 0 | 3 | 6:8 | -2 | 6 | |
| 5. | Las Vegas Lights | 5 | 0 | 2 | 3 | 8:12 | -4 | 2 | |
| # | Group C | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 5 | 3 | 2 | 0 | 7:1 | 6 | 11 | |
| 2. | New Mexico | 5 | 2 | 1 | 2 | 6:5 | 1 | 7 | |
| 3. | Colorado Springs | 5 | 1 | 2 | 2 | 4:6 | -2 | 5 | |
| 4. | Real Monarchs | 5 | 0 | 1 | 4 | 2:9 | -7 | 1 | |
| # | Group D | MP | W | D | L | G | GD | Pts | Form |
| 1. | FC Tulsa | 5 | 3 | 2 | 0 | 9:5 | 4 | 11 | |
| 2. | Austin Bold | 5 | 2 | 1 | 2 | 8:6 | 2 | 7 | |
| 3. | Rio Grande | 5 | 2 | 0 | 3 | 10:10 | 0 | 6 | |
| 4. | San Antonio | 5 | 2 | 0 | 3 | 7:7 | 0 | 6 | |
| 5. | Oklahoma City Energy | 5 | 0 | 2 | 3 | 5:10 | -5 | 2 | |
| # | Group E | MP | W | D | L | G | GD | Pts | Form |
| 1. | Louisville City | 5 | 5 | 0 | 0 | 12:2 | 10 | 15 | |
| 2. | Saint Louis FC | 5 | 2 | 1 | 2 | 6:8 | -2 | 7 | |
| 3. | Indy Eleven | 5 | 1 | 1 | 3 | 5:8 | -3 | 4 | |
| 4. | Sporting Kansas City II | 5 | 1 | 0 | 4 | 6:12 | -6 | 3 | |
| # | Group F | MP | W | D | L | G | GD | Pts | Form |
| 1. | Hartford Athletic | 5 | 4 | 1 | 0 | 10:3 | 7 | 13 | |
| 2. | Pittsburgh | 5 | 4 | 0 | 1 | 11:2 | 9 | 12 | |
| 3. | New York Red Bulls 2 | 5 | 1 | 0 | 4 | 9:17 | -8 | 3 | |
| 4. | Philadelphia Union II | 5 | 0 | 1 | 4 | 8:14 | -6 | 1 | |
| 5. | Loudoun | 5 | 0 | 1 | 4 | 2:11 | -9 | 1 | |
| # | Group G | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charlotte Independ. | 5 | 3 | 1 | 1 | 6:4 | 2 | 10 | |
| 2. | North Carolina | 5 | 3 | 0 | 2 | 8:5 | 3 | 9 | |
| 3. | Memphis | 5 | 3 | 0 | 2 | 12:11 | 1 | 9 | |
| 4. | Birmingham | 5 | 1 | 1 | 3 | 8:9 | -1 | 4 | |
| # | Group H | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charleston | 5 | 3 | 1 | 1 | 9:6 | 3 | 10 | |
| 2. | Tampa Bay | 5 | 3 | 0 | 2 | 6:4 | 2 | 9 | |
| 3. | Miami FC | 5 | 2 | 1 | 2 | 7:7 | 0 | 7 | |
| 4. | Atlanta United 2 | 5 | 2 | 0 | 3 | 10:11 | -1 | 6 |
| # | Group A | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Reno | 10 | 7 | 3 | 0 | 33:16 | 17 | 24 | |
| 2. | Sacramento Republic | 10 | 6 | 3 | 1 | 21:12 | 9 | 21 | |
| 3. | Portland Timbers 2 | 10 | 3 | 0 | 7 | 16:27 | -11 | 9 | |
| 4. | Tacoma Defiance | 10 | 2 | 1 | 7 | 12:22 | -10 | 7 | |
| # | Group B | MP | W | D | L | G | GD | Pts | Form |
| 1. | Phoenix Rising | 10 | 7 | 1 | 2 | 27:11 | 16 | 22 | |
| 2. | Ventura County | 10 | 5 | 2 | 3 | 20:21 | -1 | 17 | |
| 3. | San Diego Loyal | 10 | 3 | 3 | 4 | 11:14 | -3 | 12 | |
| 4. | Orange County SC | 10 | 3 | 1 | 6 | 11:16 | -5 | 10 | |
| 5. | Las Vegas Lights | 10 | 1 | 3 | 6 | 16:25 | -9 | 6 | |
| # | Group C | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 10 | 7 | 3 | 0 | 15:5 | 10 | 24 | |
| 2. | New Mexico | 10 | 5 | 2 | 3 | 14:12 | 2 | 17 | |
| 3. | Colorado Springs | 10 | 1 | 6 | 3 | 10:15 | -5 | 9 | |
| 4. | Real Monarchs | 10 | 2 | 1 | 7 | 9:16 | -7 | 7 | |
| # | Group D | MP | W | D | L | G | GD | Pts | Form |
| 1. | San Antonio | 10 | 6 | 1 | 3 | 20:11 | 9 | 19 | |
| 2. | FC Tulsa | 10 | 4 | 4 | 2 | 15:13 | 2 | 16 | |
| 3. | Austin Bold | 10 | 3 | 5 | 2 | 19:16 | 3 | 14 | |
| 4. | Rio Grande | 10 | 2 | 1 | 7 | 14:20 | -6 | 7 | |
| 5. | Oklahoma City Energy | 10 | 0 | 5 | 5 | 6:18 | -12 | 5 | |
| # | Group E | MP | W | D | L | G | GD | Pts | Form |
| 1. | Louisville City | 10 | 9 | 1 | 0 | 23:5 | 18 | 28 | |
| 2. | Saint Louis FC | 10 | 4 | 3 | 3 | 15:16 | -1 | 15 | |
| 3. | Sporting Kansas City II | 10 | 3 | 0 | 7 | 15:23 | -8 | 9 | |
| 4. | Indy Eleven | 10 | 2 | 2 | 6 | 8:14 | -6 | 8 | |
| # | Group F | MP | W | D | L | G | GD | Pts | Form |
| 1. | Pittsburgh | 10 | 7 | 1 | 2 | 21:5 | 16 | 22 | |
| 2. | Hartford Athletic | 10 | 6 | 2 | 2 | 17:15 | 2 | 20 | |
| 3. | New York Red Bulls 2 | 10 | 3 | 0 | 7 | 20:26 | -6 | 9 | |
| 4. | Philadelphia Union II | 10 | 1 | 2 | 7 | 14:25 | -11 | 5 | |
| 5. | Loudoun | 10 | 1 | 2 | 7 | 8:21 | -13 | 5 | |
| # | Group G | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charlotte Independ. | 10 | 6 | 1 | 3 | 14:11 | 3 | 19 | |
| 2. | North Carolina | 10 | 4 | 0 | 6 | 13:16 | -3 | 12 | |
| 3. | Birmingham | 10 | 3 | 3 | 4 | 18:15 | 3 | 12 | |
| 4. | Memphis | 10 | 3 | 2 | 5 | 17:20 | -3 | 11 | |
| # | Group H | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charleston | 10 | 7 | 2 | 1 | 20:10 | 10 | 23 | |
| 2. | Tampa Bay | 10 | 6 | 1 | 3 | 14:7 | 7 | 19 | |
| 3. | Miami FC | 10 | 3 | 2 | 5 | 11:19 | -8 | 11 | |
| 4. | Atlanta United 2 | 10 | 2 | 1 | 7 | 15:21 | -6 | 7 |
| # | Group A | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Reno | 15 | 10 | 3 | 2 | 40:20 | 20 | 33 | |
| 2. | Sacramento Republic | 15 | 8 | 5 | 2 | 26:16 | 10 | 29 | |
| 3. | Tacoma Defiance | 15 | 4 | 2 | 9 | 24:29 | -5 | 14 | |
| 4. | Portland Timbers 2 | 15 | 3 | 0 | 12 | 19:44 | -25 | 9 | |
| # | Group B | MP | W | D | L | G | GD | Pts | Form |
| 1. | Phoenix Rising | 15 | 10 | 2 | 3 | 40:16 | 24 | 32 | |
| 2. | Orange County SC | 15 | 7 | 2 | 6 | 18:18 | 0 | 23 | |
| 3. | Ventura County | 15 | 7 | 2 | 6 | 24:31 | -7 | 23 | |
| 4. | San Diego Loyal | 15 | 6 | 4 | 5 | 16:17 | -1 | 22 | |
| 5. | Las Vegas Lights | 15 | 2 | 4 | 9 | 23:33 | -10 | 10 | |
| # | Group C | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 15 | 9 | 4 | 2 | 24:14 | 10 | 31 | |
| 2. | New Mexico | 15 | 8 | 3 | 4 | 23:17 | 6 | 27 | |
| 3. | Real Monarchs | 15 | 3 | 2 | 10 | 14:24 | -10 | 11 | |
| 4. | Colorado Springs | 15 | 1 | 7 | 7 | 17:27 | -10 | 10 | |
| # | Group D | MP | W | D | L | G | GD | Pts | Form |
| 1. | San Antonio | 15 | 9 | 3 | 3 | 29:14 | 15 | 30 | |
| 2. | FC Tulsa | 15 | 6 | 7 | 2 | 21:16 | 5 | 25 | |
| 3. | Austin Bold | 15 | 4 | 7 | 4 | 29:27 | 2 | 19 | |
| 4. | Oklahoma City Energy | 15 | 1 | 7 | 7 | 11:27 | -16 | 10 | |
| 5. | Rio Grande | 14 | 2 | 3 | 9 | 17:28 | -11 | 9 | |
| # | Group E | MP | W | D | L | G | GD | Pts | Form |
| 1. | Louisville City | 15 | 10 | 2 | 3 | 27:12 | 15 | 32 | |
| 2. | Saint Louis FC | 15 | 6 | 4 | 5 | 18:20 | -2 | 22 | |
| 3. | Indy Eleven | 15 | 6 | 2 | 7 | 17:17 | 0 | 20 | |
| 4. | Sporting Kansas City II | 15 | 5 | 1 | 9 | 20:28 | -8 | 16 | |
| # | Group F | MP | W | D | L | G | GD | Pts | Form |
| 1. | Hartford Athletic | 15 | 10 | 2 | 3 | 30:24 | 6 | 32 | |
| 2. | Pittsburgh | 15 | 10 | 1 | 4 | 36:9 | 27 | 31 | |
| 3. | New York Red Bulls 2 | 15 | 5 | 0 | 10 | 30:36 | -6 | 15 | |
| 4. | Philadelphia Union II | 15 | 2 | 2 | 11 | 20:45 | -25 | 8 | |
| 5. | Loudoun | 13 | 1 | 3 | 9 | 10:28 | -18 | 6 | |
| # | Group G | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charlotte Independ. | 15 | 7 | 4 | 4 | 22:21 | 1 | 25 | |
| 2. | Birmingham | 15 | 6 | 4 | 5 | 26:19 | 7 | 22 | |
| 3. | North Carolina | 15 | 6 | 1 | 8 | 17:21 | -4 | 19 | |
| 4. | Memphis | 15 | 4 | 4 | 7 | 24:31 | -7 | 16 | |
| # | Group H | MP | W | D | L | G | GD | Pts | Form |
| 1. | Tampa Bay | 15 | 9 | 3 | 3 | 24:11 | 13 | 30 | |
| 2. | Charleston | 15 | 9 | 3 | 3 | 26:15 | 11 | 30 | |
| 3. | Miami FC | 15 | 4 | 4 | 7 | 19:30 | -11 | 16 | |
| 4. | Atlanta United 2 | 15 | 3 | 3 | 9 | 23:32 | -9 | 12 |
| # | Group A | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Reno | 16 | 11 | 3 | 2 | 43:21 | 22 | 36 | |
| 2. | Sacramento Republic | 16 | 8 | 6 | 2 | 27:17 | 10 | 30 | |
| 3. | Tacoma Defiance | 16 | 4 | 2 | 10 | 25:32 | -7 | 14 | |
| 4. | Portland Timbers 2 | 16 | 3 | 0 | 13 | 20:50 | -30 | 9 | |
| # | Group B | MP | W | D | L | G | GD | Pts | Form |
| 1. | Phoenix Rising | 16 | 11 | 2 | 3 | 46:17 | 29 | 35 | |
| 2. | Ventura County | 16 | 8 | 2 | 6 | 29:32 | -3 | 26 | |
| 3. | Orange County SC | 16 | 7 | 3 | 6 | 18:18 | 0 | 24 | |
| 4. | San Diego Loyal | 16 | 6 | 5 | 5 | 17:18 | -1 | 23 | |
| 5. | Las Vegas Lights | 16 | 2 | 5 | 9 | 24:34 | -10 | 11 | |
| # | Group C | MP | W | D | L | G | GD | Pts | Form |
| 1. | El Paso | 16 | 9 | 5 | 2 | 24:14 | 10 | 32 | |
| 2. | New Mexico | 15 | 8 | 3 | 4 | 23:17 | 6 | 27 | |
| 3. | Colorado Springs | 16 | 2 | 7 | 7 | 19:28 | -9 | 13 | |
| 4. | Real Monarchs | 16 | 3 | 2 | 11 | 14:25 | -11 | 11 | |
| # | Group D | MP | W | D | L | G | GD | Pts | Form |
| 1. | San Antonio | 16 | 10 | 3 | 3 | 30:14 | 16 | 33 | |
| 2. | FC Tulsa | 15 | 6 | 7 | 2 | 21:16 | 5 | 25 | |
| 3. | Austin Bold | 16 | 5 | 7 | 4 | 30:27 | 3 | 22 | |
| 4. | Oklahoma City Energy | 16 | 1 | 7 | 8 | 12:29 | -17 | 10 | |
| 5. | Rio Grande | 14 | 2 | 3 | 9 | 17:28 | -11 | 9 | |
| # | Group E | MP | W | D | L | G | GD | Pts | Form |
| 1. | Louisville City | 16 | 11 | 2 | 3 | 28:12 | 16 | 35 | |
| 2. | Saint Louis FC | 16 | 7 | 4 | 5 | 22:21 | 1 | 25 | |
| 3. | Indy Eleven | 16 | 7 | 2 | 7 | 21:19 | 2 | 23 | |
| 4. | Sporting Kansas City II | 16 | 5 | 1 | 10 | 21:30 | -9 | 16 | |
| # | Group F | MP | W | D | L | G | GD | Pts | Form |
| 1. | Hartford Athletic | 16 | 11 | 2 | 3 | 31:24 | 7 | 35 | |
| 2. | Pittsburgh | 16 | 11 | 1 | 4 | 39:10 | 29 | 34 | |
| 3. | New York Red Bulls 2 | 16 | 5 | 0 | 11 | 30:37 | -7 | 15 | |
| 4. | Philadelphia Union II | 16 | 2 | 3 | 11 | 20:45 | -25 | 9 | |
| 5. | Loudoun | 13 | 1 | 3 | 9 | 10:28 | -18 | 6 | |
| # | Group G | MP | W | D | L | G | GD | Pts | Form |
| 1. | Charlotte Independ. | 16 | 8 | 4 | 4 | 24:22 | 2 | 28 | |
| 2. | Birmingham | 16 | 7 | 4 | 5 | 29:19 | 10 | 25 | |
| 3. | North Carolina | 15 | 6 | 1 | 8 | 17:21 | -4 | 19 | |
| 4. | Memphis | 15 | 4 | 4 | 7 | 24:31 | -7 | 16 | |
| # | Group H | MP | W | D | L | G | GD | Pts | Form |
| 1. | Tampa Bay | 16 | 10 | 3 | 3 | 25:11 | 14 | 33 | |
| 2. | Charleston | 15 | 9 | 3 | 3 | 26:15 | 11 | 30 | |
| 3. | Miami FC | 16 | 4 | 4 | 8 | 20:34 | -14 | 16 | |
| 4. | Atlanta United 2 | 16 | 3 | 3 | 10 | 23:33 | -10 | 12 |